[OPTICAL REVIEW Vol. 10, No. 2 (2003) 74-76]
© 2003 The Optical Society of Japan

Temperature-Insensitive Measurement of Glucose Concentration Based on Near Infrared Spectroscopy and Partial Least Squares Analysis

Hidenobu ARIMOTO1, Masatoshi TARUMI2 and Yukio YAMADA1,3

1Institute of Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, AIST Tsukuba East, Tsukuba, Ibaraki 305-8564, Japan
2Nikkiso Co., Ltd., 498-1 Shizutani, Haibara, Shizuoka 421-0496, Japan
3Department of Mechanical Engineering and Intelligent Systems, University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan

(Received August 1, 2002; Accepted December 9, 2002; Revised November 11, 2002)

Temperature-insensitive partial least squares analysis for glucose measurement is presented based on Near Infrared spectroscopy in the wavelength range from 1,250 to 1,800 nm. Experiments are performed using aqueous glucose solutions. To create a temperature-insensitive prediction model, the glucose concentration and water temperature are varied independently. The results of the predicted glucose concentration agree well with the actual glucose concentration with an error of 4.4%.

Key words: blood glucose measurement, non-invasive measurement, multivariate analysis, PLS, NIR spectroscopy