[OPTICAL REVIEW Vol. 10, No. 3 (2003) 161-165]
© 2003 The Optical Society of Japan

Instrumental Requirements for Non-Invasive Blood Glucose Measurement Using NIR Spectroscopy

Hidenobu ARIMOTO1, Masatoshi TARUMI2 and Yukio YAMADA1,3

1Institute of Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, AIST Tsukuba East, Tsukuba, Ibaraki 305-8564, Japan
2Nikkiso Co. Ltd., 498-1 Sizutani, Haibara, Sizuoka 421-0496, Japan
3Department of Mechanical Engineering and Intelligent Systems, University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan

(Received August 5, 2002; Accepted January 28, 2003; Revised December 3, 2002)

The magnitude of spectral change in blood glucose measurements with diffuse reflectance spectroscopy is investigated. Spectral change is estimated by simulation of light propagation in skin tissue and measurements of absorbance spectra of aqueous glucose solution. Required sensitivity of spectrophotometers for monitoring change in the blood glucose concentration as small as 10 mg/dL has been obtained using the estimated change in the absorbance spectrum and mean pathlength of light in tissue.

Key words: blood glucose measurement, non-invasive measurement, Monte Carlo simulation, NIR spectroscopy, scattering