[OPTICAL REVIEW Vol. 12, No. 3 (2005) 202-206]
© 2005 The Optical Society of Japan

Multiple-Scattering-Free Optical Glucose Monitoring Based on Femtosecond Pulse Interferometry

Yasuaki HORI, Takeshi YASUI and Tsutomu ARAKI

Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan

(Received September 30, 2004; Accepted February 15, 2005)

We have designed a novel multiple-scattering-free optical glucose monitoring system based on femtosecond pulse interferometry. The glucose concentration is determined by a time-of-flight method, while multiple-scattering light is rejected by a coherence gate. The resultant accuracy and precision were 94.7 and 24.5 mg/dl, respectively, for physiological-equivalent glucose concentrations in a scattering medium of 1.0% intralipid solution, while the accuracy and precision for a reference sample containing no scattering medium were 65.3 and 23.8 mg/dl, respectively. Comparing these results, we conclude that the proposed method is effective for glucose measurement in a scattering medium.

Key words: glucose, femtosecond pulse light, multiple scattering, coherence gate, interferometry, time-of-flight, group refractive index