[OPTICAL REVIEW Vol. 13, No. 1 (2006) 29-33]
© 2006 The Optical Society of Japan

Optical Glucose Monitoring Based on Femtosecond Two-Color Pulse Interferometry

Yasuaki HORI, Takeshi YASUI and Tsutomu ARAKI

Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan

(Received April 27, 2005; Accepted October 5, 2005)

We demonstrate the potential of femtosecond two-color pulse interferometry for in vitro optical glucose monitoring, by dispersion of the group refractive index in a glucose solution sample with respect to a red-color light and a blue-color light. By comparison with femtosecond one-color pulse interferometry, the basic performance of the present system with regard to sensitivity, quantitativeness, and tolerance to surrounding disturbances, is evaluated. The resulting accuracy and precision of glucose determination are 77 and 118 mg/dl for 10-mm-sample-thickness, respectively. This near-common-path configuration of the two-color pulse light provides good stability to fluctuations of sample temperature, which is important in clinical applications. Considering the performance of femtosecond two-color pulse interferometry as an optical glucose sensor, a suitable measurement site for in vivo optical glucose monitoring is discussed.

Key words: glucose, femtosecond two-color pulse light, multiple scattering, coherence gate, interferometry, time-of-flight, group refractive index