Kazuo KASAHARA and Toshiharu SAIKI^*

Graduate School of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama 223-8522, Japan

(Received February 2, 2010; Accepted December 10, 2010)

Fluorescence correlation spectroscopy (FCS) of colloidal nanoparticles using a near-field fiber probe was numerically simulated. The near-wall dynamics was simulated by accounting for the anisotropic mobility of nanoparticles owing to hydrodynamic interaction with a wall (Stokes viscous force). By comparing the simulation results with theoretical model calculations, we found that the influence of anisotropic diffusion is insignificant in near-field FCS autocorrelation analysis.

Key words: near-field optical microscopy, fluorescence correlation spectroscopy, hydrodynamics, diffusion coefficient

^*E-mail address: saiki@elec.keio.ac.jp